How long does the protection from a mother’s immunization versus influenza throughout pregnancy last for children after they are born?
Marta C. Nunes, Ph.D., of the University of the Witwatersrand, Johannesburg, South Africa, and coauthors sought to answer that questions in an write-up published online by JAMA Pediatrics. It’s an crucial question since the incidence of influenza among children is higher and health problem can easily induce hospitalizations and death. Also, current vaccines don’t job well in children much less compared to 6 months of age and are not licensed for usage in that age group.
Infants born to women that participated in a randomized clinical trial of trivalent inactivated influenza vaccine (IIV3) once they were pregnant were followed up to find out the vaccine’s efficacy versus influenza and baby antibody levels throughout their very first 6 months of life.
Analysis of the vaccine’s efficacy included 1,026 children born to women immunized along with IIV3 and 1,023 children born to women offered placebo. The vaccine’s efficacy versus influenza health problem was highest once children were 8 weeks or younger at 85.6 percent yet minimized as the children grew to 25.5 percent among children 8 to 16 weeks and to 30.3 percent among children 16 to 24 weeks, according to the results.
Additionally, in a subset of infants, the percentage of children along with antibodies at or above a certain degree dropped from 56 percent in the very first week of life to much less compared to 10 percent at 24 weeks of age.
Study limitations consist of that the very same IIV3 formulation was used in the 2 study years.
“We and others have actually previously displayed that the administration of IIV3 throughout pregnancy confers protection versus symptomatic influenza infection to the children of the vaccinated mothers; listed here we reveal that the duration of this protection is most likely to be restricted to the very first 8 weeks of age. Many potential mechanisms of protection have actually been proposed … Our study suggests that the a lot of most likely mechanism of protection of the children is through the transplacental transfer of maternal antibodies,” the authors conclude.
(JAMA Pediatr. Published online July 5, 2016. doi:10.1001/jamapediatrics.2016.0921. Readily available pre-embargo to the media at http://media. jamanetwork. com.)
Editor’s Note: The study entails conflict of interest and funding/sustain disclosures. Please observe write-up for Extra information, including others authors, author contributions and affiliations, etc.
Editorial: baby Protection versus Influenza Through Maternal Immunization
“The study of Nunes et al contributes substantially to our knowing of baby protection versus influenza through maternal vaccination,” Flor M. Munoz, M.D., of the Baylor College of Medicine, Houston, writes in a related editorial.
(JAMA Pediatr. Published online July 5, 2016. doi:10.1001/jamapediatrics.2016.1322. Readily available pre-embargo to the media at http://media. jamanetwork. com.)
Editor’s Note: Please observe write-up for Extra information, including others authors, author contributions and affiliations, etc.
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Media Advisory: To contact study author Marta C. Nunes, Ph.D., email nunesm@rmpru.co.za. To contact editorial author Flor M. Munoz, M.D., call Dipali Pathak at 713-798-4710 or email pathak@bcm.edu.
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