Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets – Journal of Virology

1. Raffael Nachbagauer^a,^b,
2. Matthew S. Miller^c,
3. Rong Hai^a*,
4. Alex B. Ryder^d,
5. John K. Rose^d,
6. Peter Palese^a,^e,
7. Adolfo García-Sastre^a,^e,^f,
8. Florian Krammer^a and
9. Randy A. Albrecht^a,^f

1. ^aDepartment of Microbiology, Icahn School of Medication at Mount Sinai, Brand-new York, Brand-new York, USA
2. ^bFaculty of Life Sciences, University of Vienna, Vienna, Austria
3. ^cDepartment of Biochemistry and Biomedical Sciences, Institute for Infectious Diseases Research, McMaster Immunology Study Centre, McMaster University, Hamilton, Ontario, Canada
4. ^dDepartment of Pathology, Yale University School of Medicine, Brand-new Haven, Connecticut, USA
5. ^eDepartment of Medicine, Icahn School of Medication at Mount Sinai, Brand-new York, Brand-new York, USA
6. ^fGlobal Good health & Emerging Pathogens Institute, Icahn School of Medication at Mount Sinai, Brand-new York, Brand-new York, USA

ABSTRACT

We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets versus aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine approach based regard viral vectors expressing chimeric hemagglutinin constructs induced stalk-individual antibody responses. Stalk-immunized ferrets were cohoused along with H1N1-infected ferrets under ailments that allowed virus transmission. Hemagglutinin stalk-immunized ferrets owned lesser viral titers and delayed or no virus replication at every one of complying with normal exposure to influenza virus.

FOOTNOTES

• • Received 27 September 2015.
  • Accepted twenty December 2015.
  • Accepted manuscript posted online 30 December 2015.
• Address correspondence to Randy A. Albrecht, randy.albrecht{at}mssm.edu, or Florian Krammer, florian.krammer{at}mssm.edu.

• ↵* Present address: Rong Hai, Department of Plant Pathology and Microbiology, University of California, Riverside, Riverside, California, USA.

• Citation Nachbagauer R, Miller MS, Hai R, Ryder AB, Flower JK, Palese P, García-Sastre A, Krammer F, Albrecht RA. 2016. Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets. J Virol 90:3268–3273. doi:10.1128/JVI.02481-15.

• Copyright © 2016, American Society for Microbiology. every one of Rights Reserved.

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